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KMID : 1145120170150040489
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Asian Journal of Beauty and Cosmetology
2017 Volume.15 No. 4 p.489 ~ p.499
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Biological Activity Study on Anti-oxidant, Whitening, and Anti-inflammatory Effects of Astragalus membranaceus Ethanol Extracts and Bioconversion Extracts
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Bae Hye-Kyung
You Seon-Hee
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Abstract
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Purpose: This study aimed to analyze the applicability of Astragalus membranaceus ethanol extracts (AM) and Astragalus membranaceus bioconversion extracts (AMB) as an ingredient in functional cosmetics.
Methods: 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical elimination, melanogenesis inhibition, melanogenesis associated transcription factor (MITF), and tyrosinase expression were evaluated. Furthermore, nitric oxide (NO) synthesis inhibition and its inhibitory effects on the expression of cyclooxygenase 2 (COX2) were evaluated.
Results: There were DPPH radical scavenging activities over 51% in 0.5% concentration of both samples. Both extraction methods had excellent melanin biosynthesis inhibition effects, and inhibitory effects on MITF expression were confirmed in the AMB. In addition, in the AMB, excellent inhibitory effects on NO production were confirmed, but COX2 inhibition effects were not great.
Conclusion: The AMB, which has anti-oxidant activity effects, is expected to be used as material for various functional cosmetic products that have whitening effects through MITF expression inhibition and anti-inflammatory effects through NO production inhibition.
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KEYWORD
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Anti-oxidant effects, Anti-inflammatory effects, Astragalus membranaceus, Bioconversion, Melanin
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